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Bug snake knows the security research of Chinese traditional medicine of series

From;    Author:Stand originally
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Experimental animal: Healthy Kunming is planted small white rat, half and half of male and female, weight 20 ± 0.5g.

Experimental method: Take small rat 20, abstinence 12h, water normally, every rat connects 0.8ml of stomach of fill of agent of decoct of soup of pain or numbness caused by cold with bug snake every time, removed 4h, total volume 2.4ml. Contain crude drug among them 18.3 (3g/Kg) , of dosage of day of quite clinical person 100 times (did not measure a LD50) . The animal after using drug did not appear apparent toxic symptom and dead circumstance, survey a week continuously, the animal survives entirely, mobile freely, hair is smooth, food is normal, breath, nose, eye, oral cavity does not have unusual secretion. Gain weight. Anatomize an animal one week later, naked eye and microscope watch main internal organs of the body, did not appear apparent pathology change.

[chronic noxiousness experiment]

Experimental animal: Rat of Wistar become known, 60 ~ 80g, 80, half and half of male and female.

Experimental method: Divide become known rat 4 groups randomly, contrast group and 3 tests group (1g/ day, 2g/ day, 4g/ day, fill stomach) . Every groups each 20, half and half of male and female. Contrast group of normal feed feed. Food of the freedom after fill stomach, observe 30 days continuously.

Detect method:

(1) the animal is behaved commonly. (2) hematic convention and blood biochemical index. Haemoglobin, red blood cell, leucocyte reachs classification. Transaminase, urea nitrogen, flesh anhydride, cholesterol, triglyceride, blood sugar, total albumen, albumin. (3) pathology examination. Liver, kidney, stomach, spermary, ovarian.

[result]

1, acute noxiousness experiment: Result of acute noxiousness test confirms, bug snake connects Chinese traditional medicine of series of pain or numbness caused by cold decoction does not have acute noxiousness action, inside quantity of stomach of the biggest fill, did not measure an apparent LD50. The clinical on the safe side that use drug did not appear apparent pathology change.

2, chronic noxiousness experiment: Bug snake connects Chinese traditional medicine of series of pain or numbness caused by cold the effect with apparent to sufferring blood picture of the week outside trying become known rat to not have decoction;

[evaluate]
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